Apigenin
precursor
Showing entry for Apigenin
Identification
- PhytoHub ID
- PHUB000861
- Name
- Apigenin
- Systematic Name
- Not Available
- Synonyms
- 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
- 5,7,4'-Trihydroxyflavone
- chamomile
- versulin
- CAS Number
- 520-36-5
- Average Mass
- 270.24
- Monoisotopic Mass
- 270.052823422
- Chemical Formula
- C15H10O5
- IUPAC Name
- 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
- InChI Key
- KZNIFHPLKGYRTM-UHFFFAOYSA-N
- InChI Identifier
InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
- SMILES
OC1=CC=C(C=C1)C1=CC(=O)C2=C(O)C=C(O)C=C2O1
- Structure
Calculated Properties
- Solubility (ALOGPS)
- 1.18e-01 g/l
- LogS (ALOGPS)
- -3.36
- LogP (ALOGPS)
- 3.07
- Hydrogen Acceptors
- 5
- Hydrogen Donors
- 3
- Rotatable Bond Count
- 1
- Polar Surface Area
- 86.99000000000001
- Refractivity
- 72.91390000000001
- Polarizability
- 26.7801790574094
- Formal Charge
- 0
- Physiological Charge
- -1
- pKa (strongest basic)
- -5.381179969028222
- pKa (strongest acidic)
- 6.574691761170129
- Number of Rings
- 3
- Rule of Five
- Yes
- Bioavailability
- Yes
- Ghose Filter
- Yes
- Veber's Rule
- No
- MDDR-like Rule
- No
External Links
- ChEBI
- 18388
- PubChem
- 5280443
- Chemistry Dashboard
- DTXSID6022391
- KNApSAcK
- C00003817
- MetaboLights
- MTBLC18388
- Phenol-Explorer
- 228
- FooDB (Compounds)
- FDB002798
- PeakForestCompound
- 000661
Taxonomy as Food Phytochemical
- Family
- Polyphenols
- Class
- Flavonoids
- Sub-class
- Flavones
Taxonomy as Metabolite
- Metabolite Family
- (Poly)phenol metabolites
- Metabolite Class
- Flavonoid metabolites
- Metabolite Sub-class
- Flavones (parent and host metabolites)
Taxonomy of its Food Phytochemical Precursor(s)
Food Phytochemical | Family | Class | Sub-class | |
---|---|---|---|---|
Apigenin | Polyphenols | Flavonoids | Flavones | Show Food Phytochemical |
Apigenin 7-O-glucoside | Polyphenols | Flavonoids | Flavones | Show Food Phytochemical |
Apigenin 7-O-rutinoside | Polyphenols | Flavonoids | Flavones | Show Food Phytochemical |
Classyfire Taxonomy
- Kingdom Name
- Organic compounds
- Class
- Flavonoids
- Super-class
- Phenylpropanoids and polyketides
- Sub-class
- Flavones
- Direct Parent Name
- Flavones
- Alternative Parent Names
- ["1-hydroxy-2-unsubstituted benzenoids", "1-hydroxy-4-unsubstituted benzenoids", "4'-hydroxyflavonoids", "5-hydroxyflavonoids", "7-hydroxyflavonoids", "Benzene and substituted derivatives", "Chromones", "Heteroaromatic compounds", "Hydrocarbon derivatives", "Organic oxides", "Organooxygen compounds", "Oxacyclic compounds", "Pyranones and derivatives", "Vinylogous acids"]
- External Descriptor Annotations
- ["Flavones and Flavonols", "flavones", "trihydroxyflavone"]
- Substituent Names
- ["1-benzopyran", "1-hydroxy-2-unsubstituted benzenoid", "1-hydroxy-4-unsubstituted benzenoid", "4'-hydroxyflavonoid", "5-hydroxyflavonoid", "7-hydroxyflavonoid", "Aromatic heteropolycyclic compound", "Benzenoid", "Benzopyran", "Chromone", "Flavone", "Heteroaromatic compound", "Hydrocarbon derivative", "Hydroxyflavonoid", "Monocyclic benzene moiety", "Organic oxide", "Organic oxygen compound", "Organoheterocyclic compound", "Organooxygen compound", "Oxacycle", "Phenol", "Pyran", "Pyranone", "Vinylogous acid"]
Spectra from Phytohub
Spectrum Type | Instrument Type | Technology | Ion Mode | Collision Energy | View | |
---|---|---|---|---|---|---|
GC-MS | GC-MS | Not Available | Not Available | Not Available | View Spectrum | |
GC-MS | GC-EI-TOF | instrument=Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies | positive | Not Available | View Spectrum | |
GC-MS | GC-EI-TOF | instrument=Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies | positive | Not Available | View Spectrum | |
GC-MS | GC-MS | Not Available | Not Available | Not Available | View Spectrum | |
Predicted GC-MS | GC-MS | Predicted by CFMID-EI, energy0 | Positive | Not Available | View Spectrum | |
Predicted GC-MS | GC-MS | Predicted by CFMID-EI, Ionization energy 70 eV fully TMS-derivatized (structure: C[Si](C)(C)OC1=CC=C(C2=CC(=O)C3=C(O[Si](C)(C)C)C=C(O[Si](C)(C)C)C=C3O2)C=C1) | Positive | Not Available | View Spectrum | |
Predicted GC-MS | GC-MS | Predicted by CFMID-EI, energy0 | Ei | Not Available | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | 30V | View Spectrum | |
LC-MS/MS | ESI-TOF | Not Available | Negative | V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | 30V | View Spectrum | |
LC-MS/MS | ESI-TOF | From Sumner Library | Negative | V | View Spectrum | |
LC-MS/MS | DI-ESI-qTof | From GNPS Library | Negative | V | View Spectrum | |
LC-MS/MS | DI-ESI-qTof | From GNPS Library | Positive | V | View Spectrum | |
LC-MS/MS | LC-ESI-qTof | From GNPS Library | Positive | V | View Spectrum | |
LC-MS/MS | LC-ESI-qTof | From GNPS Library | Positive | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=maXis (Bruker Daltonics) | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=maXis (Bruker Daltonics) | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=maXis (Bruker Daltonics) | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=maXis (Bruker Daltonics) | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=maXis (Bruker Daltonics) | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=UPLC Q-Tof Premier, Waters | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=UPLC Q-Tof Premier, Waters | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=UPLC Q-Tof Premier, Waters | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=Agilent 1200 RRLC; Agilent 6520 QTOF | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=Agilent 1200 RRLC; Agilent 6520 QTOF | negative | V | View Spectrum | |
LC-MS/MS | LC-ESI-QTOF | instrument=Agilent 1200 RRLC; Agilent 6520 QTOF | negative | V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Positive | 10V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Positive | 20V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Positive | 40V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Negative | 10V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Negative | 20V | View Spectrum | |
Predicted LC-MS/MS | Not Available | Predicted by CFM-ID | Negative | 40V | View Spectrum |
Food Sources
Name | Group | |||
---|---|---|---|---|
Celery leaves | Herbs and Spices | Publications | Show | |
Celery stalks | Vegetables, Other vegetables | Publications | Show | |
Chamomile tea | Teas and herbal teas | Publications | Show | |
Common oregano | Herbs and Spices | Publications | Show | |
Globe artichoke | Vegetables, Other vegetables | Publications | Show | |
Olive, black | Fruit, Drupes | Publications | Show | |
Olive, green | Fruit, Drupes | Publications | Show | |
Parsley | Herbs and Spices | Publications | Show |
Food Sources of its Food Phytochemical(s)
Food Phytochemical | Food Source | Food Source Group | |||
---|---|---|---|---|---|
Apigenin | Celery leaves | Herbs and Spices | Publications | Show | |
Apigenin | Celery stalks | Vegetables, Other vegetables | Publications | Show | |
Apigenin | Chamomile tea | Teas and herbal teas | Publications | Show | |
Apigenin | Common oregano | Herbs and Spices | Publications | Show | |
Apigenin | Globe artichoke | Vegetables, Other vegetables | Publications | Show | |
Apigenin 7-O-glucoside | Globe artichoke | Vegetables, Other vegetables | Publications | Show | |
Apigenin 7-O-rutinoside | Globe artichoke | Vegetables, Other vegetables | Publications | Show | |
Apigenin | Olive, black | Fruit, Drupes | Publications | Show | |
Apigenin 7-O-glucoside | Olive, black | Fruit, Drupes | Publications | Show | |
Apigenin 7-O-rutinoside | Olive, black | Fruit, Drupes | Publications | Show | |
Apigenin | Olive, green | Fruit, Drupes | Publications | Show | |
Apigenin | Parsley | Herbs and Spices | Publications | Show | |
Apigenin 7-O-rutinoside | Peppermint | Herbs and Spices | Publications | Show | |
Apigenin 7-O-glucoside | Roman camomile | Herbs and Spices | Publications | Show |
Role as Biomarker of intake
No roles as Biomarker of intake found
Metabolism
Food Phytochemical | Metabolite | Species | Biofluids | Origin | TMax | CMax | Urinary Excretion | Formula | Monoisotopic mass | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Apigenin | Apigenin | human | urine | unchanged | No data | No data | <1% | C15H10O5 | 270.052823422 | Publications | |||
Apigenin | Apigenin 7-O-glucuronide | human | plasma, urine | host metabolism | 1h-3h | <20nmol/L | <1% | C21H18O11 | 446.0849114 | Detailed Intervention Studies | Publications | ||
Apigenin | Apigenin 4'-O-glucuronide | human | plasma, urine | host metabolism | Not Available | Not Available | <1% | C21H18O11 | 446.0849114 | Publications | |||
Apigenin 7-O-glucoside | Apigenin | human | Not Available | Not Available | Not Available | Not Available | Not Available | C15H10O5 | 270.052823422 | ||||
Apigenin 7-O-rutinoside | Apigenin | human | Not Available | Not Available | Not Available | Not Available | Not Available | C15H10O5 | 270.052823422 |
Inter-Individual Variations in Metabolism
Food Phytochemical | Metabolite | Effect | Value |
---|