Ferulic acid
precursor
Showing entry for Ferulic acid
Identification
- PhytoHub ID
- PHUB000608
- Name
- Ferulic acid
- Systematic Name
- 4’-hydroxy-3’-methoxycinnamic acid
- Synonyms
- 3-(4-hydroxy-3-methoxyphenyl)acrylic acid
- 3-Methoxy-4-hydroxycinnamic acid
- 4-Hydroxy-3-methoxycinnamic acid
- 4’-hydroxy-3’-methoxycinnamic acid
- trans-ferulic acid
- CAS Number
- 537-98-4
- Average Mass
- 194.186
- Monoisotopic Mass
- 194.057908802
- Chemical Formula
- C10H10O4
- IUPAC Name
- (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
- InChI Key
- KSEBMYQBYZTDHS-HWKANZROSA-N
- InChI Identifier
InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
- SMILES
COC1=C(O)C=CC(\C=C\C(O)=O)=C1
- Structure
Calculated Properties
- Solubility (ALOGPS)
- 9.06e-01 g/l
- LogS (ALOGPS)
- -2.33
- LogP (ALOGPS)
- 1.58
- Hydrogen Acceptors
- 4
- Hydrogen Donors
- 2
- Rotatable Bond Count
- 3
- Polar Surface Area
- 66.76
- Refractivity
- 51.50400000000002
- Polarizability
- 19.349332656403057
- Formal Charge
- 0
- Physiological Charge
- -1
- pKa (strongest basic)
- -4.893961534479146
- pKa (strongest acidic)
- 3.5753044752877954
- Number of Rings
- 1
- Rule of Five
- Yes
- Bioavailability
- Yes
- Ghose Filter
- Yes
- Veber's Rule
- No
- MDDR-like Rule
- No
External Links
- ChEBI
- 17620
- PubChem
- 445858
- MetaboLights
- MTBLC17620
- PeakForestCompound
- 000472
Taxonomy as Food Phytochemical
- Family
- Polyphenols
- Class
- Phenolic acids
- Sub-class
- Hydroxycinnamic acids
Taxonomy as Metabolite
- Metabolite Family
- (Poly)phenol metabolites
- Metabolite Class
- Phenolic acid metabolites
- Metabolite Sub-class
- Cinnamic acids
Taxonomy of its Food Phytochemical Precursor(s)
Classyfire Taxonomy
- Kingdom Name
- Organic compounds
- Class
- Cinnamic acids and derivatives
- Super-class
- Phenylpropanoids and polyketides
- Sub-class
- Hydroxycinnamic acids and derivatives
- Direct Parent Name
- Hydroxycinnamic acids
- Alternative Parent Names
- ["1-hydroxy-2-unsubstituted benzenoids", "Alkyl aryl ethers", "Anisoles", "Carbonyl compounds", "Carboxylic acids", "Cinnamic acids", "Coumaric acids and derivatives", "Hydrocarbon derivatives", "Methoxybenzenes", "Methoxyphenols", "Monocarboxylic acids and derivatives", "Organic oxides", "Phenoxy compounds", "Styrenes"]
- External Descriptor Annotations
- ["Coniferyl alcohol derivatives", "ferulic acids"]
- Substituent Names
- ["1-hydroxy-2-unsubstituted benzenoid", "Alkyl aryl ether", "Anisole", "Aromatic homomonocyclic compound", "Benzenoid", "Carbonyl group", "Carboxylic acid", "Carboxylic acid derivative", "Cinnamic acid", "Coumaric acid or derivatives", "Ether", "Hydrocarbon derivative", "Hydroxycinnamic acid", "Methoxybenzene", "Methoxyphenol", "Monocarboxylic acid or derivatives", "Monocyclic benzene moiety", "Organic oxide", "Organic oxygen compound", "Organooxygen compound", "Phenol", "Phenol ether", "Phenoxy compound", "Styrene"]
Spectra from Online Resources
Record ID | Source | Description | View |
---|---|---|---|
JP002207 | MassBank | EI-B Spectrum - -, [M]+* | View Spectra |
JP007239 | MassBank | EI-B Spectrum - -, [M]+* | View Spectra |
JP011305 | MassBank | EI-B Spectrum - -, [M]+* | View Spectra |
JP011308 | MassBank | EI-B Spectrum - -, [M]+* | View Spectra |
KO001106 | MassBank | LC-ESI-QQ Spectrum - 10 V, unspecified | View Spectra |
KO001107 | MassBank | LC-ESI-QQ Spectrum - 20 V, unspecified | View Spectra |
KO001108 | MassBank | LC-ESI-QQ Spectrum - 30 V, unspecified | View Spectra |
KO001109 | MassBank | LC-ESI-QQ Spectrum - 40 V, unspecified | View Spectra |
KO001110 | MassBank | LC-ESI-QQ Spectrum - 50 V, unspecified | View Spectra |
KZ000089 | MassBank | GC-EI-TOF Spectrum - -, unspecified | View Spectra |
KZ000133 | MassBank | GC-EI-TOF Spectrum - -, unspecified | View Spectra |
OUF00227 | MassBank | GC-EI-TOF Spectrum - -, unspecified | View Spectra |
PR010004 | MassBank | GC-EI-TOF Spectrum - -, unspecified | View Spectra |
PR100004 | MassBank | LC-ESI-QTOF Spectrum - Ramp 5-60 V, unspecified | View Spectra |
PR100005 | MassBank | LC-ESI-QTOF Spectrum - 30 V, unspecified | View Spectra |
PR100482 | MassBank | LC-ESI-QTOF Spectrum - Ramp 5-60 V, unspecified | View Spectra |
PS001101 | ReSpect | N/A Spectrum - 10, [M+H]+ | View Spectra |
PS001102 | ReSpect | N/A Spectrum - 20, [M+H]+ | View Spectra |
PS001103 | ReSpect | N/A Spectrum - 30, [M+H]+ | View Spectra |
PS103901 | ReSpect | N/A Spectrum - 10, [M+H]+ | View Spectra |
PS103902 | ReSpect | N/A Spectrum - 20, [M+H]+ | View Spectra |
PS103907 | ReSpect | N/A Spectrum - 10, [M-H]- | View Spectra |
Food Sources
Food Sources of its Food Phytochemical(s)
Role as Biomarker of intake
No roles as Biomarker of intake found
Metabolism
Food Phytochemical | Metabolite | Species | Biofluids | Origin | TMax | CMax | Urinary Excretion | Formula | Monoisotopic mass | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ferulic acid | 3-Hydroxybenzoic acid | human rat | plasma, urine | gut microbiota metabolite | Not Available | Not Available | Not Available | C7H6O3 | 138.031694053 | Publications | |||
Ferulic acid | p-Hydroxybenzoic acid | human | plasma, urine | Not Available | Not Available | Not Available | Not Available | C7H6O3 | 138.031694053 | Publications | |||
Ferulic acid | Protocatechuic acid | human | plasma, urine | Not Available | Not Available | Not Available | Not Available | C7H6O4 | 154.026608673 | Publications | |||
Ferulic acid | Vanillic acid | human rat | urine | Not Available | Not Available | Not Available | Not Available | C8H8O4 | 168.042258738 | Publications | |||
Ferulic acid | 3',4'-Dihydroxyphenylacetic acid | human in vitro (human) rat | urine | gut microbiota metabolite | Not Available | Not Available | Not Available | C8H8O4 | 168.042258738 | Publications | |||
Ferulic acid | Dihydrocaffeic acid | human | urine | gut microbiota metabolite | Not Available | Not Available | Not Available | C9H10O4 | 182.057908802 | ||||
Ferulic acid | Phloretic acid | human | urine | host metabolism | Not Available | Not Available | Not Available | C9H10O3 | 166.062994182 | ||||
Ferulic acid | Ferulic acid | human | plasma, urine | unchanged | 1h-3h | 20-50 nmol/L | <1% | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Ferulic acid | 3-(3'-Hydroxyphenyl)propionic acid | human rat | plasma, urine | gut microbiota metabolite | Not Available | Not Available | Not Available | C9H10O3 | 166.062994182 | ||||
Ferulic acid | 3-Phenylpropionic acid | human | plasma | gut microbiota metabolite | Not Available | Not Available | Not Available | C9H10O2 | 150.068079562 | ||||
Ferulic acid | Dihydroferulic acid | rat | urine | Not Available | Not Available | Not Available | Not Available | C10H12O4 | 196.073558866 | Publications | |||
Ferulic acid | Ferulic acid-4'-O-glucuronide | rat | urine | Not Available | Not Available | Not Available | Not Available | C16H18O10 | 370.08999678 | Publications | |||
Ferulic acid | Ferulic acid-4'-sulfate | human rat | plasma, urine | host metabolism | 1h-3h | 50-200 nmol/L | 1-5% | C10H10O7S | 274.014723836 | Detailed Intervention Studies | Publications | ||
Ferulic acid | Ferulic acid sulfoglucuronide | rat | plasma | Not Available | Not Available | Not Available | Not Available | C16H18O13S | 450.375513 | Publications | |||
Ferulic acid | Feruloylglycine | human rat | urine | host-gut microbiota co-metabolite | Not Available | Not Available | 10-30% | C12H13NO5 | 251.079372523 | Detailed Intervention Studies | Publications | ||
Ferulic acid | Hippuric acid | human | plasma, urine | host-gut microbiota co-metabolite | Not Available | Not Available | Not Available | C9H9NO3 | 179.058243154 | Publications | |||
Ferulic acid | Vanilloyl-glycine | rat | urine | Not Available | Not Available | Not Available | Not Available | C10H11NO5 | 225.063722458 | Publications | |||
Ferulic acid | veratric acid | human | plasma, urine | host metabolism | Not Available | Not Available | Not Available | C9H10O4 | 182.057908802 | Publications | |||
Ferulic acid | Sinapic acid-O-sulfate | human | urine | host metabolism | Not Available | Not Available | <1% | C11H12O8S | 304.02528852 | Detailed Intervention Studies | Publications | ||
Ferulic acid | Dihydroferulic acid-4'-O-glucuronide | human | urine | host-gut microbiota co-metabolite | Not Available | Not Available | 1-5% | C16H20O10 | 372.105646844 | Detailed Intervention Studies | Publications | ||
Ferulic acid | Dihydroferulic acid-4'-sulfate | human | plasma, urine | host-gut microbiota co-metabolite | 5h-8h | 20-50 nmol/L | 1-5% | C10H12O7S | 276.0303739 | Detailed Intervention Studies | Publications | ||
Ferulic acid | Dihydrocaffeic acid-3-sulfate | human | urine | host-gut microbiota co-metabolite | Not Available | Not Available | <1% | C9H10O7S | 262.014723836 | Detailed Intervention Studies | Publications | ||
Ferulic acid | Ferulic acid glucuronide | human | plasma | host metabolism | 1h-3h | 0.5-2µmol/L | Not Available | Detailed Intervention Studies | Publications | ||||
Cyanidin 3-O-glucoside | Ferulic acid | human | feces, serum, urine | Not Available | Not Available | Not Available | Not Available | C10H10O4 | 194.057908802 | Publications | |||
Caffeic acid | Ferulic acid | human rat | plasma, urine | host metabolism | Not Available | Not Available | Not Available | C10H10O4 | 194.057908802 | Publications | |||
5-O-Caffeoylquinic acid | Ferulic acid | rat | plasma, urine | host metabolism | Not Available | Not Available | Not Available | C10H10O4 | 194.057908802 | Publications | |||
Orange flavanones | Ferulic acid | human | plasma, urine | host-gut microbiota co-metabolite | 1h-3h | <20 nmol/L | <1% | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Cocoa Flavan-3-ols | Ferulic acid | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | |||
Black tea Flavan-3-ols | Ferulic acid | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | |||
Blueberry (Poly)phenols | Ferulic acid | human | plasma | host metabolism | 1h-3h | <20 nmol/L | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Coffee Chlorogenic acids | Ferulic acid | human | plasma | host metabolism | 1h-3h | 50-200 nmol/L | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Grape (Poly)phenols | Ferulic acid | human | plasma | host metabolism | 1h-3h | 50-200 nmol/L | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Wheat (Poly)phenols | Ferulic acid | human | serum | host metabolism | 1h-3h | <20 nmol/L | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Rosemary tea (poly)phenols | Ferulic acid | human | plasma | host-gut microbiota co-metabolite | 5h-8h | 50-200 nmol/L | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Olive oil (Poly)phenols | Ferulic acid | human | plasma | host-gut microbiota co-metabolite | Not Available | 200-500 nmol/L | Not Available | C10H10O4 | 194.057908802 | Detailed Intervention Studies | |||
Cranberry (Poly)phenols | Ferulic acid | human | plasma, urine | host-gut microbiota co-metabolite | 8h-12h | 50-200 nmol/L | <1% | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Globe artichoke (Poly)phenols | Ferulic acid | human | plasma, urine | host-gut microbiota co-metabolite | 5h-8h | 0.5-2µmol/L | 1-5% | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Cyanidin-3-glucoside | Ferulic acid | human | serum, urine | host-gut microbiota co-metabolite | 8h-12h | 0.5-2µmol/L | <1% | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Red Raspberries Anthocyanins | Ferulic acid | human | urine | host-gut microbiota co-metabolite | Not Available | Not Available | 1-5% | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications | ||
Tomato (Poly)phenols | Ferulic acid | human | urine | host-gut microbiota co-metabolite | Not Available | Not Available | 10-30% | C10H10O4 | 194.057908802 | Detailed Intervention Studies | Publications |
Inter-Individual Variations in Metabolism
Food Phytochemical | Metabolite | Effect | Value | |||
---|---|---|---|---|---|---|
Ferulic acid | Ferulic acid | Sex | No effect | Publications | ||
Coffee Chlorogenic acids | Ferulic acid | Microbiota | Effect, clusters | Publications | ||
Globe artichoke (Poly)phenols | Ferulic acid | Microbiota | Effect, clusters | Publications | ||
Tomato (Poly)phenols | Ferulic acid | Microbiota | Effect, clusters | Publications |